These were refined further using LASSO regression analysis (Figures 2B, C), resulting in the identification of nine key genes (ATL2, MKRN1, FBXW8, FBXO8, DCAF16, WSB1, CHFR, MDM2, SOCS2) that were found to be strongly associated with the prognosis of ALL patients, as determined by univariate (Supplementary Figure 1) and multivariate COX regression analyses. The gene discussed is FBXW8; the disease is acute lymphoblastic leukemia.