The results demonstrated that among the significantly enriched top 5 pathways, high expression of CD19 and GPR65 was markedly co-enriched in oxidative phosphorylation, ribosome, Alzheimer’s disease, and Parkinson’s disease, whereas low expression of GPR65 was significantly enriched in olfactory transduction (P.adjust < 0.05) (Figures 4A, B). Here, CD19 is linked to early-onset autosomal dominant Alzheimer disease.