SQSTM1 and Krabbe disease: Similarly, a study by Lin et al. on globoid cell leukodystrophy (GLD) revealed that impairment of both the UPS and autophagy led to the accumulation of ubiquitin and p62 aggregates, particularly in the white matter of the brain and spinal cord, contributing to neuroinflammation and demyelination (Lin et al., 2020).