Through two-sample bidirectional MR analysis, filtering for IVW P-values > 0.05 identified GCNT2, PIGN, KREMEN1, GCDH, CD93, CCDC77, and HSD17B13 as genetic risk proteins associated with PCOS and SHBG levels (Supplementary Figure S2). This evidence concerns the gene PIGN and polycystic ovary syndrome.