Through two-sample bidirectional MR analysis, filtering for IVW P-values > 0.05 identified GCNT2, PIGN, KREMEN1, GCDH, CD93, CCDC77, and HSD17B13 as genetic risk proteins associated with PCOS and SHBG levels (Supplementary Figure S2). Here, GCDH is linked to polycystic ovary syndrome.