Through two-sample bidirectional MR analysis, filtering for IVW P-values > 0.05 identified GCNT2, PIGN, KREMEN1, GCDH, CD93, CCDC77, and HSD17B13 as genetic risk proteins associated with PCOS and SHBG levels (Supplementary Figure S2). The gene discussed is KREMEN1; the disease is polycystic ovary syndrome.