Previous systematic assessments have shown that obesity may contribute to inflammation in several ways, on the one hand, adipose tissue is not only a storage of energy in the body, but is also capable of secreting a variety of adipokines (known as adipokines), including leptin, lipocalin, tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), among others. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.