One study highlighted elevated serum levels of adhesion molecules such as soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, and E-selection in obese individuals with atherosclerosis compared to non-obese controls, suggesting that obesity exacerbates endothelial impairment (23). The gene discussed is ICAM1; the disease is obesity due to melanocortin 4 receptor deficiency.