COL1A1 and myopia: Based on the above results, we believe that after injecting rhBMP2 into the vitreous cavity of LIM guinea pigs, rhBMP2 can bind to the BMP2-related receptors, activate the Smad signaling pathway, affect the expression of MMP2/TIMP2, promote the expression of Col1A1 gene, regulate scleral remodeling, promote collagen I synthesis, and delay the development of myopia.