Moreover, downregulation of this enzyme reduced the tumor burden in models of hepatocellular carcinoma (Comerford et al., 2014) and acetyl-CoA transferase ACAT1 was downregulated in A549 tumors following treatment with MTDIA (Basu et al., 2011), and the yeast orthologues were downregulated in meu1Δ cells. This evidence concerns the gene ACAT1 and neoplasm.