ACAT1 and hepatocellular carcinoma: Moreover, downregulation of this enzyme reduced the tumor burden in models of hepatocellular carcinoma (Comerford et al., 2014) and acetyl-CoA transferase ACAT1 was downregulated in A549 tumors following treatment with MTDIA (Basu et al., 2011), and the yeast orthologues were downregulated in meu1Δ cells.