Vps34 relocalizes from vacuoles/lysosomes to subdomains of the ER upon starvation (Burman and Ktistakis, 2010) and exogenously added phosphoinositide 3-kinase induces autophagy in human colon cancer cells (Petiot et al., 2000). Here, PIK3C3 is linked to malignant colon neoplasm.