CD8A and cancer: Given that iCAFs could cause apoptosis in CD8+ T cells and decrease anti‐cancer immunity through interplaying with CD8+ T cells PTPRC receptors by Galectin‐1 (LGALS1) based on literature review [77, 78], we explored the ligand‐receptor interactions (LRIs) of LGALS1‐PTPRC (Figure 5E,J,O,T), and found that the interplay distances of LGALS1‐PTPRC LRI were closer in non‐responders than in responders (Figure S6E).