Given that iCAFs could cause apoptosis in CD8+ T cells and decrease anti‐cancer immunity through interplaying with CD8+ T cells PTPRC receptors by Galectin‐1 (LGALS1) based on literature review [77, 78], we explored the ligand‐receptor interactions (LRIs) of LGALS1‐PTPRC (Figure 5E,J,O,T), and found that the interplay distances of LGALS1‐PTPRC LRI were closer in non‐responders than in responders (Figure S6E). Here, PTPRC is linked to cancer.