Intriguingly, we found that the iCAF marker gene Gelsolin (GSN), with favourable prognosis value in ccRCC (Figure S7F), was up‐regulated in not only iCAFs from responders in the pan‐cancer landscape (Figure 6A), but also iCAFs from responders in the RCC cohort (Figure S7A), suggesting its possibly favourable function in the ICI response of RCC. This evidence concerns the gene GSN and nonpapillary renal cell carcinoma.