ESR1 and cancer: Among non-overweight women, the antidepressant- breast cancer association was not dependent on ER status, but it was particularly strong for ER negative cancer: ER positive (HR = 0.83, 95%CI = 0.69–1.00) and ER negative (HR = 0.55, 95%CI = 0.32–0.95) (Table 3).