NLRP3 and arthritic joint disease: It is reported that NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome triggered by TGR5-cAMP-PKA axis play a direct role in arthritis inflammation [11, 25], we therefore further determined the levels of NLRP3, ASC, caspase-1 p20, and IL-1β p17.