However, proteins with relative increased abundance in C9orf72 ALS compared to sALS (such as NEFL, NEFM, IGHM, and ADH1B) included those with axonal regeneration ontology as well as proteins with metabolic pathways associated with L-ascorbic acid, cellular ketone, and cellular aldehyde. The gene discussed is NEFL; the disease is amyotrophic lateral sclerosis.