However, proteins with relative increased abundance in C9orf72 ALS compared to sALS (such as NEFL, NEFM, IGHM, and ADH1B) included those with axonal regeneration ontology as well as proteins with metabolic pathways associated with L-ascorbic acid, cellular ketone, and cellular aldehyde. This evidence concerns the gene IGHM and amyotrophic lateral sclerosis.