Although the combination of ASAP/GAAD and 5 DMMs demonstrated the highest sensitivity for early HCC detection, the AIC value (−154.16 versus −169.97) suggested that this formula's complexity is greater than that of the combination of ASAP/GAAD and FOXD3. Additionally, no statistically significant difference was observed when comparing the combined model to the ASAP/GAAD score alone. This evidence concerns the gene FOXD3 and hepatocellular carcinoma.