For overall HCC, the performance improved for most biomarkers, with the combination of the ASAP/GAAD and 5 DMMs as well as the ASAP/GAAD and FOXD3 achieving the highest AUC of 0.833 (72.9% sensitivity, 81.3% specificity) and 0.811 (69.5% sensitivity, 81.3% specificity), respectively, surpassing that of the ASAP/GAAD score (62.7% sensitivity, 81.3% specificity) or the 5 DMMs alone (35.6–44.1% sensitivity, 81.3% specificity). This evidence concerns the gene FOXD3 and hepatocellular carcinoma.