SPAG6 and hepatocellular carcinoma: The selected DMMs were FGF19, NKX2-4, SPAG6, FOXD3, NRIP3, NKX3-2, TBX4, TSPYL5, GRASP, BOP1, and C8orf82. DNA methylation scores for the 11 DMMs that were significantly higher in 5 out of 6 cirrhotic HCC liver tissues compared to cirrhotic controls (Fig. 3A).