STRIT1 and dilated cardiomyopathy: Upregulated DWORF expression has been shown to restore Ca2+cycling and cardiac function in a mouse model of dilated cardiomyopathy (Makarewich 2018)and can promote cardioprotection in isolated rat hearts subjected to I/R (Mbikou et al. 2020); however, no previous study confirmed a cardioprotective effect of DWORF administered during cardiac reperfusion after an ischemic event in vivo or identified the factors controlling cardiac DWORF expression.