Finally, while light-induced retinal degeneration serves as an established model system (Grimm and Reme 2019), comprehensive evaluation of LCN2's role in retinal degeneration would benefit from additional experimental approaches, including pigmented animal models, genetic models recapitulating AMD or RP pathology and LCN2-knockout models. The gene discussed is LCN2; the disease is age-related macular degeneration.