Our results show that Gal-8 expression decreases after AKI and remains lower for at least 14 days, contrasting with other galectins, such as Gal-1, Gal-3, and Gal-9, which have been reported to increase during injury (Vansthertem et al. 2010; Kolatsi-Joannou et al. 2011; Prud'homme et al. 2019; Volarevic et al. 2019; Kulow et al. 2024). This evidence concerns the gene LGALS8 and acute kidney injury.