Among these, Gal-3 is the most studied and has been implicated in either protective (Volarevic et al. 2019; Kulow et al. 2024) or pro-fibrotic effects after kidney damage (Henderson et al. 2008; Kolatsi-Joannou et al. 2011; Martinez-Martinez et al. 2016; Li et al. 2018; Volarevic et al. 2019; Hermenean et al. 2022; Marino et al. 2023; Perez-Moreno et al. 2024a), depending on the model studied. This evidence concerns the gene LGALS3 and Nephropathy.