LGALS8 and Sepsis: Interestingly, the immunoregulatory functions of Gal-8 can be disrupted by function-blocking anti-Gal-8 autoantibodies, which have been detected in autoimmune and inflammatory conditions, including sepsis (Carcamo et al. 2006; Massardo et al. 2009; Vicuna et al. 2013; Pardo et al. 2017, 2019).