ATM and systemic sclerosis: In fact, histologic evaluation of digital arteries from patients with SSc demonstrates intimal hyperplasia, adventitial fibrosis, resulting in greater than 75% luminal narrowing and intraluminal thrombosis [30] In clinical practice, the presence of this symptomatic complex, along with ATA seropositivity, may be highly predictive of DU development and may drive more adequate preventive measures and treatment regimens [3, 15, 31].