MLLT3 and acute myeloid leukemia: DOT1L (Disruptor of Telomeric silencing 1-Like) is associated with KMT2A fusion proteins (Fig. 1) in KMT2A-rearranged AML, as it interacts with many of the known fusion partner proteins of KMT2A, such as AFF1 (also known as AF4), and MLLT3 (also known as AF9).