To map the epigenetic and transcriptional landscape at single-cell level, we performed single-cell multiome sequencing (scMultiome-seq), which combines ATAC and gene expression analyses on WT and GFI1ΔCD8 P14 CD8+ T cells isolated at day 7 after LCMVc13 infection (Extended Data Fig. 8a). Here, CD8A is linked to infection.