SHBG and breast carcinoma: We have reported that analyses of cytokines and adipokines from the pooled Reach for Health (RFH) and MetBreCS trials, which included a total of 352 overweight/obese breast cancer survivors, demonstrated significant changes in leptin, sex hormone-binding globulin (SHGB) and C-reactive protein (CRP) levels following metformin and lifestyle interventions24.