SELP and neoplasm: This compound stimulates the activity of multiple matrix metalloproteinases in cancer cells, aiding in the detachment of tumor cells from their primary location and promoting their invasion into the circulatory system.354 In addition, tumor cells rely on CD15 binding to P-selectin to adhere to platelets, and the adhered platelets enhance the proliferation and migration characteristics of tumor cells by increasing the adhesion between tumor cells and endothelial cells.355