TLR4 and Sepsis: This was accompanied by a significant decrease in cGMP levels and abnormal distribution of platelet AGs, which was mediated by the PI3K-AKt-GSK3β pathway.410 Besides, platelet mitochondrial damage and elevated intracellular ROS play a crucial role in promoting platelet aggregation through the LPS/TLR4 pathway, which involves phosphorylation of AKT, PKC, and p38.411 A study on 18 sepsis patients found that during the initial stage of sepsis-induced platelet mitochondrial uncoupling, there is a soluble plasma factor that does not inhibit the electron transport system.