GP6 and Sepsis: Mitochondrial uncoupling accompanied by gradual and significant increase in respiratory capacity.412 However, persistent mitochondrial dysfunction and respiratory chain enzyme inhibition will further affect platelet reactivity to exogenous agonists, as well as impaired aggregation and secretion.413 In addition, immune receptors such as GPVI and CLEC-2 also play important roles.414 Clinical trials have indicated that GPVI dysfunction in sepsis occurs prior to a significant drop in platelet count.