PRKN and diabetes mellitus: Prolonged exposure of platelets to elevated glucose concentrations can result in alterations to platelet mitochondrial function, including heightened oxygen consumption and an increase in mitochondrial membrane potential,427 causing excessive production of ROS, and exacerbates platelet activation.428 Moreover, Parkin is involved in mitochondrial quality control through the process of mitophagy and is significantly expressed in platelets, both in healthy individuals and those with diabetes.