For instance, ZNF350 enhances ferroptosis in glioma cells by reducing transcriptional repression of NCOA4, thereby promoting glioma progression, elevating STING levels to increase NCOA4 binding, enhancing ferroptosis in renal tubular epithelial cells, and exacerbating acute kidney injury [49, 50]. The gene discussed is STING1; the disease is central nervous system cancer.