USP18 and central nervous system cancer: Through ChIP and reporter gene assays, we identified the specific binding site of YY1 in the promoter region of USP18. To the best of our knowledge, this is the first study to explore the mechanism underlying USP18 overexpression in gliomas and the transcriptional regulatory relationship between YY1 and USP18, thus providing new insights into the upstream and downstream molecular biological mechanisms driving the oncogenic effects of USP18.