Sittler and colleagues reported higher levels of endosomal markers (Rab7 and Rab1A) and large vesicles accumulating electron-dense materials in brain tissue of MJD patients [22], demonstrating that MJD cells have impairments in the endosomal pathway, which is associated with the production of some EVs, such as exosomes [10]. This evidence concerns the gene RAB1A and Machado-Joseph disease.