PDK1 and posterior cortical atrophy: In this study, we aimed to investigate the effects of 1 on the proliferation and metastasis of PCa cells; CWR22Rv1 (22Rv1), C4-2, and PC-3 through affect key signaling, including p-AKT, p-mTOR, p-STAT3, HSP90 HSP70 ErbB4, and PDK1.