Heredia-Rodriguez et al.23noted that combining PCT and WBC (four times the cut-off value) within the first three postoperative days predicted postoperative infection within 30 days of heart surgery with an AUC of 0.842 (95 % CI: 0.789–0.886) in 423 pediatric patients undergoing open-heart surgery with CPB. This evidence concerns the gene CALCA and infection.