Lamping et al., in a study of 230 adult ICU patients with SIRS/sepsis, reported that a diagnostic model combining four clinical parameters and four laboratory parameters (IL-6, platelet count, PCT, CRP) had better diagnostic value for infection than individual tests or combining CRP and PCT, with an AUC of 0.78 (95 % CI: 0.70–0.87).22 This evidence concerns the gene CALCA and systemic inflammatory response syndrome.