The latter model efficiently reconstitutes human T cells as well as natural killer (NK) cells,46,47 thus enabling Fc-dependent effector functions to act along with fragment antigen binding (Fab)-mediated Env inactivation.17,46 A recent study in reconstituted MISTRG-IL15 mice highlighted how NK cells help control HIV infection via ADCC when recruited by PGT121.17 The gene discussed is ERVW-1; the disease is HIV infectious disease.