A supervised analysis of RNA-seq from human JAK2V617F neutrophils56 supported this possibility, since CD24 (not CD47) mRNA expression and gene signatures corelated with degranulation and protease-rich azurophil granules in JAK2V617F MPN neutrophils (Figure 6A-B; supplemental Figure 8A-C). This evidence concerns the gene CD47 and myeloproliferative disorder.