Among the five top genes associated with the prediction of PFS (LRP2, NAT8, ACE2, CYP4A11 and EMX2), it is interesting that all of them have been associated with RCC prognosis (PMIDs: 36851274,36980716, 34630525, 34976818, 34704468, 38183818, 37065178). This evidence concerns the gene NAT8 and renal cell carcinoma.