PINLYP and infection: In line with the above observation, there were more RFP-positive, KSHV-infected 293T cells after infection with the supernatant from Dox-treated PINLYP KO cells as compared to the cells infected with the supernatant from WT cells (S1B and S1C Fig), suggesting PINLYP deficiency leads to increased viral production during KSHV lytic reactivation.