To further investigate the function of PINLYP during gammaherpesvirus latent infection, we measured the kinetics of PINLYP expression during de novo infection of HUVEC with KSHV since KSHV infection of HUVEC undergoes a temporary lytic phase at the early stage of infection and ultimately establishes tight latency at the late stage [36]. The gene discussed is PINLYP; the disease is disease arising from reactivation of latent virus.