PINLYP and infection: When compared with the 293T cells infected with the supernatant from vector-transfected iSLK.RGB cells, a significant lower number of RFP-positive 293T cells were observed after infection with the supernatant from PINLYP-transfected iSLK.RGB cells (Fig 3F), suggesting that PINLYP overexpression results in a decrease in infectious virion production in Dox-treated iSLK.RGB cells.