FUT8 plays a key role in the progression of head and neck squamous cell carcinoma (HNSCC) by mediating abnormal N-glycosylation of SEMA7A, which this study suggests causes CD8 + T cells to differentiate into a depleted state, forming an immunosuppressive microenvironment that is resistant to immunotherapy. This evidence concerns the gene FUT8 and head and neck squamous cell carcinoma.