Phenome-wide association study data suggested that modulating DGKD, CASR, CYP24A1, or SLC34A1 may result in target-mediated adverse effects including alterations in serum bilirubin, inflammatory bowel disease, migraine, atopic dermatitis, and eczematous phenotypes (Supplemental Data 4) (9). This evidence concerns the gene CASR and inflammatory bowel disease.