Since Rb itself has been increasingly studied in the context of its role in the organism, it has been suggested as a potential marker of obesity (Szczerbowska-Boruchowska et al. 2023a),(Szczerbowska-Boruchowska et al. 2023b), (Tinkov et al. 2015), (Ziomber-Lisiak et al. 2022a), (Amerikanou et al. 2023). This evidence concerns the gene RB1 and obesity due to melanocortin 4 receptor deficiency.