CAPNS1 upregulation in T2D hearts is associated with calpain/CAPNS1-mediated Junctophilin2 (Jp2) hydrolysis and nuclear translocation, suggesting CAPNS1 as a potential therapeutic target for adverse prognostics in T2D patients with SARS-CoV-2 infection [109]. Here, JPH2 is linked to type 2 diabetes mellitus.