In PCOS, excess androgen islinked to a rise in belly fat, which causes hyperinsulinemia and dyslipidemia.To raise the amounts of circulating bioactive testosterone, hyperinsulinemiadecreases the amount of hepatic sex hormone-binding globulin (SHBG) (Dumesic et al., 2015). This evidence concerns the gene SHBG and polycystic ovary syndrome.