Logistic regression analysis (Table 3) adjusted for age, sex, education, ACE I/D genotypes, APOEε4 status, and hypertension, revealing that age (p < 0.001) and sex (p = 0.014) were significantly associated with GM volume; age (p < 0.001), sex (p < 0.001), and hypertension (p = 0.033) with CSF volume; and sex with TIV (p < 0.001). The gene discussed is ACE; the disease is hypertensive disorder.