Furthermore, HNSCC exhibited significantly elevated SLC2A1 mRNA expression compared with both normal esophageal mucosa (Fig. 1D) and pan-cancer cell lines (Supplementary Fig. S1D), and GLUT1 protein expression was observed to be higher in HNSCC tumors than in normal tissue (Supplementary Fig. S1E). This evidence concerns the gene SLC2A1 and cancer.