To investigate whether genetic ablation of GLUT1 in the Krt5+ basal progenitor cells—potential cells of origin of SCC—might effectively inhibit or halt squamous cancer progression after tumor initiation, we established a tamoxifen-inducible knockout mouse model (Krt5:creER; LSL-dTomato; Trp53+/−; Slc2a1loxP/loxP; detailed in “Materials and Methods”). The gene discussed is TP53; the disease is neoplasm.