We identified a robust upregulation of GLUT1 (SLC2A1), a key rate-limiting factor in the transport of glucose in cancer cells, and genes involved in central glucose metabolism (HK2, ENO1, PKM, and LDHA), PPP (G6PD), and de novo serine biosynthesis pathway (PSAT1, PSPH, and SHMT2; Fig. 1A). Here, SHMT2 is linked to cancer.