In the past two decades, numerous studies on adult and paediatric patients with fatty liver have demonstrated that carriers of the common PNPLA3 (patatin‐like phospholipase domain‐containing protein, also known as adiponutrin) variant p.I148M are at increased risk of developing hepatic steatosis,377, 378, 379 fibrosis and cirrhosis,380 as well as HCC.381. The gene discussed is PNPLA3; the disease is fatty liver disease.