INS and metabolic syndrome: Moreover, significantly improved insulin sensitivity and blood pressure was observed in the high-dose intervention group.25 To address the mode of action, a single duodenal delivery of A. soehngenii strain L2–7 to metabolic syndrome subjects was found to improve glycemic control while increasing postprandial plasma GLP-1 levels, with a concomitant significant increase in small intestinal expression of the gene coding for regenerating islet protein 1B (Reg1B) synthesis.26 Additionally, secondary bile salts were increased upon this duodenal administration.