It is important to note that unlike AD progression in humans, AD mouse models generated by overexpressing AD‐related mutant gene(s), including APP, MAPT, and PSEN1, start to express the transgenes from developmental stages and develop pathological changes at an early age, meaning a younger and more responsive state for OPCs, likely impacting neuronal development per se in these mice. This evidence concerns the gene MAPT and Alzheimer disease.