The Neuropathology core provides final neuropathology reports to families and also submits forms capturing neuropathology data (e.g., information on the extent of beta‐amyloid plaque and neurofibrillary tangle accumulation, cerebrovascular pathology, Lewy bodies, TDP‐43, and other descriptors) to the National Alzheimer disease Coordinating Center for inclusion in analyses conducted by international studies. The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.