An improved histological score, with a reduction in subacute inflammation and in the severity of lesions, such as gland damage/loss, erosions, and epithelial hyperplasia, and an increased colon length measured in ecto-TMEM219-treated mice compared with untreated mice demonstrated that TMEM219 blockade exerts a protective effect in an immunological-mediated colitis model (Figure 5, E–G). This evidence concerns the gene TMEM219 and colitis.