On confocal analysis, MUC5AC was strongly colocalized with VCAN-V1 in A549-scramble cells in the tumor matrix region, but this localization was completely abrogated in MUC5AC-KD cells (Figure 5G), suggesting that MUC5AC modulates VCAN-V1 for tumor matrix remodeling during angiogenesis and tumor development. This evidence concerns the gene MUC5AC and neoplasm.