In support of this finding, we observed reduced ST6GalNAc-I, MUC5AC, and VCAN-V1 in ST6GalNAc-I/MUC5AC–depleted lung tumor tissues, suggesting that the ST6GalNAc-I/MUC5AC axis is required for lung cancer liver metastasis. Here, ST6GALNAC1 is linked to lung cancer.