BTK and cancer: Based on this strategy, we focused on candidates that appeared in at least 2 of the orthogonal screens or are putative ubiquitinated substrates of UBE2N, which included several key regulators of cancer cells, such as TIMM13 (96, 97), STAT3 (98–104), BTK (105–107), IRAK4 (108–113), NPM1 (114–116), IKKβ (117, 118), and SYNCRIP (119, 120) (Figure 3J).