Collagen Type I Alpha 1 Chain (COL1A1) and Lysyl Oxidase (LOX) were included as they were upregulated across the three solid stress compression (Supplementary Figure S6A) and are important in modulating the tumour microenvironment as well as promoting cancer migration (Payne et al., 2005; Liu et al., 2018). This evidence concerns the gene LOX and cancer.