GBA1 and Gaucher disease: Gene conversion leads to sequence diversity, contributing to the evolutionary trajectory of gene families like the human leukocyte antigen (HLA) loci that require high variability for environmental adaptability (Adamek et al., 2015) but also contributes to numerous genetic diseases, such as Gaucher Disease, an autosomal recessive lysosome storage disorder caused by mutations in GBA1 (Chen et al., 2007; Hruska et al., 2008).