In OC, NF-κB and COX-2 pathways are core pathways involved in the anti-inflammatory and anti-tumor activities of NSAIDs, including sulindac, which can effectively reduce the transcription of growth factors, chemokines, and proteases that are elevated in OC (Altinoz and Korkmaz, 2004). The gene discussed is NFKB1; the disease is neoplasm.