Spearman’s correlation analysis revealed a negative correlation between hypsarrhythmia and serum IGF-1 levels (−0.5841 [95% CI, −0.8158 to −0.1906], P = 0.0054), IGF-1/IGFBP-3 ratio (−0.6675 [95% CI, −0.8570 to −0.3191], P = 0.0009), indicating that lower IGF-1 levels and IGF-1/IGFBP-3 ratios were associated with a higher likelihood of hypsarrhythmia. This evidence concerns the gene IGFBP3 and Hypsarrhythmia.