In a previous article, Hu et al. (2022) found that key genes of the retinoic acid signaling pathway such as RXRA and its downstream genes, including HOX and SOX gene family, were significantly enriched in the patients with endometrial atypical hyperplasia and EC who did not respond to progestin therapy by ATAC-Seq and RNA-Seq integration analysis. This evidence concerns the gene RXRA and atypical endometrial hyperplasia.