Emerging evidence suggested that TRβ could act as a tumor suppressor in some solid tumors such as hepatocellular carcinoma, breast cancer, ovarian cancer, renal cell carcinoma, and thyroid cancer (Bolf et al., 2021; Davidson et al., 2021; Zhi et al., 2024; Zhu and Cheng, 2024). Here, THRB is linked to neoplasm.