For antihypertensive WM, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs), and diuretics are recommended as the initial treatment options for hypertension in international and Chinese guidelines (Whelton et al., 2018; Writing Group of Chinese Guidelines for the Management of Hypertension et al., 2019; McEvoy et al., 2024). This evidence concerns the gene ACE and hypertensive disorder.